Study suggests genetic connection between short stature and arthritis

January 10, 2008
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ANN ARBOR—Common genetic variants linked to arthritis may also play a role in human height, a new study shows.

The international study was co-led by the University of Michigan School of Public Health. The journal Nature Genetics will publish the findings online Jan. 13.

The new study confirms observations by health professionals of a connection between decreased height and increased risk of osteoarthritis, the most common form of arthritis. Researchers speculate that both extremes of height may be associated with osteoarthritis for different reasons. Shorter bones and/or less cartilage may render the joints more susceptible to damage, while longer bones may produce greater levels of damaging stress on the joints.

The findings are exciting for several reasons, said Gon